Diet Pills That Make You Lose Weight – Side effects are part of why GlaxoSmithKline’s Alli, the first over-the-counter diet pill, works for dieters. Richard Drew / AP
When the fat-blocking drug Alli hit drugstore shelves last June, hopeful consumers clamored for the first government-approved weight-loss drug. But it didn’t take long, and for some no real weight loss at all, to convince many dieters that Alli wasn’t the only answer to their weight problems.
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In addition to Alli, there are about six prescription weight loss drugs on the market. Some, like Alli, block the absorption of fat in the body. Others work on the brain to suppress appetite. But the reality is that no matter how many weight loss pills you take, they won’t work on their own.
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“The pills we have don’t seem to be very effective for long-term weight loss,” says Anne Fletcher, a registered dietitian in Mankato, Minnesota. “When people stop taking the pill, many put the weight back on.”
However, the pharmaceutical industry and many dieters are still convinced that the Pill is the answer to the growing obesity epidemic. Several new ones, including the experimental drug lorcaserin, a variant of Fen-phen. At least 30 companies are developing weight loss drugs, and experts estimate that over the next few years there will be 10 to 15 drugs designed to help people lose weight in different ways. Decision Resources, a pharmaceutical research firm, predicts that the US obesity drug market will grow from $222 million in 2006 to nearly $2 billion in 2016.
Combined with diet and exercise, obesity medications can help you lose about 5 to 10 percent more weight, studies show. However, because different pills affect the body in different ways, it’s possible that some people are better suited to one type of pill than others.
For example, a study that looked at the differences between sibutramine (Meridia) and orlistat (Xenical and Alli) found that orlistat produced greater weight loss in people who could be described as “conscientious”, meaning they had a personality more organized. oriented or aware. So careful monitoring of fat intake works for them. People who have trouble controlling their eating habits saw a greater effect with sibutramine, which affects serotonin in the brain and makes you feel full more quickly when you eat.
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Typically, the biggest mistake people make when using diet pills is seeing them as magic bullets.
“People can’t expect medicine to do this for them,” says Gary Foster, director of the Center for Obesity Research and Education at Temple University in Philadelphia. “It’s a 50/50 partnership, and the pills are half of the equation. What we eat and our lifestyle… are essential for long-term success.
When customers order weight-loss pills, Fletcher, author of Thin for Life, tells them to think of it as “one leg on a four-legged stool.”
“A leg is a physical activity; one is diet; one is behavior change and the last part can be diet pills,” he says. “Remove all the legs that hold the diet pills and the stool will fall out.”
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Fletcher found in his research that people who lost significant amounts of weight often had to try to lose weight several times before achieving long-term success.
“When trying to change any behavior, it takes most of us a few tries to get it right,” he says.
There is no real information about the long-term safety of the pills, especially for young people. However, the Food and Drug Administration has only approved them for adults for a maximum of two years of continuous use. According to an analysis of 30 studies in which adults took obesity medications for one to four years, about 30 to 40% stopped taking them after one year, although it’s not clear why.
Also, side effects are common. Sibutramine may increase blood pressure and heart rate in some patients. Orlistat, which alters the absorption of dietary fat, can have troublesome side effects in the gut. Rimonabant (used in Europe but awaiting approval in that country) can cause nausea, anxiety, depression and insomnia in some users.
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However, for obese people — people with a BMI of 30 or more — the benefits of prescription drugs may outweigh the risks, experts say.
“The most successful people are those who are willing to make a serious commitment to weight loss and take responsibility for their actions and changes,” says Pat Baird, registered dietitian and nutrition consultant in the Consumer Healthcare division of GlaxoSmithKline, who acts as an online moderator for people using All. He talks to 25 people a day and asks about weight loss, the program and the pills.
Baird admits that the side effects are part of why Alli works for some people. If someone eats more than the prescribed 15 grams of fat per meal, they can experience unpleasant digestive problems. “It helps people stay honest,” he says. LA JOLLA researchers have developed an entirely new pill that tricks the body into thinking it has consumed calories, causing it to burn fat. The compound effectively stopped weight gain, lowered cholesterol, controlled blood sugar and reduced inflammation in mice, making it an excellent candidate for rapid transition to human clinical trials.
Unlike most diet pills on the market, this new pill, called fexaramine, does not dissolve in the blood like appetite suppressants or caffeine-based diet pills, but instead stays in the gut, causing fewer side effects.
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Gene Expression Laboratory director Ronald Evans has developed a compound called fexaramine that acts like an imaginary meal. Fexaramine, which makes the body react as if it has consumed calories, could lead to the effective treatment of obesity and diabetes in humans.
“This pill is like an imaginary meal,” says Ronald Evans, director of the Gene Expression Laboratory and senior author of a new paper published Jan. 5, 2015 in the journal Nature Medicine. “It sends the same signals that normally happen when you eat too much food, so the body starts to make room to store it. But there is no change in calories or appetite.
According to the Centers for Disease Control and Prevention, more than one-third of American adults are obese and 29.1 million people have diabetes. Both obesity and diabetes increase health care costs, increase the risk of health complications and reduce life expectancy.
Institute researchers have developed a fat-burning compound called fexaramine, which causes weight loss without the side effects typical of animal models. Fexaramine causes the body to react as if it has consumed calories, which may lead to the effective treatment of type 2 diabetes and obesity in humans.
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Evans’ lab has spent nearly two decades studying the farnesoid X receptor (FXR), a protein that plays a role in how the body releases bile acids from the liver, digests food, and stores fats and sugars. The human body turns on FXR at the start of a meal, as Evans and others have shown, to prepare for a flood of food. In addition to causing the release of bile acids for digestion, FXR also alters blood sugar levels and causes the body to burn fat in preparation for a meal.
Pharmaceutical companies aiming to treat obesity, diabetes, liver disease and other metabolic disorders have developed systemic drugs that activate FXR and many of the pathways controlled by FXR. But these drugs affect various organs and have side effects. Evans wondered if activating FXR only in the gut, rather than in the gut, liver, kidneys and adrenals all at once, might lead to a different result.
Researchers have shown that fexaramine stops weight gain and burns fat in animal models. Fexaramine is absorbed only in the intestine and does not enter the bloodstream, so it does not cause the side effects of typical diet pills. After further testing, researchers believe this will lead to an effective weight loss treatment for diabetics.
“When you eat, you need to quickly activate a series of reactions throughout your body,” says Evans. “And the reality is, the first response to all of this is the gut.”
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Evans and his colleagues developed the fexaramine compound to bypass the standard drugs that most pharmaceutical companies typically use to target FXR. “It turns out that when we give it orally, it only works in the gut,” explains Michael Downs, senior researcher and co-author of the new paper. Administering one of these drugs in the form of a daily pill that only enters the gut without the bloodstream and can transport the drug throughout the body would not only reduce side effects but also improve the compound’s ability to stop weight gain. .
When the team gave obese mice a fexaramine pill every day for five weeks, the mice stopped gaining weight, lost fat and had lower blood sugar and cholesterol levels than untreated mice. In addition, the mice’s body temperature rose, indicating an increase in metabolism, and some of the white fat layers in their bodies became healthier,
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